Graminn® suppositories

GRAMINN®

SUPPOSITORIES

GRAMINN® suppositories are medical device indicated as the additional therapy of local symptoms (tingling, pain) related to the acute and chronic prostatitis, problems with hemorrhoids and development of anal fissures and fistulas.

Prostatitis
Hemorhoidal disease

Indications for GRAMINN® suppositories?

  • Non-bacterial and bacterial acute and chronic prostatitis
  • Chronic pelvic pain syndrome
  • Anorectal diseases
  • Haemorrhoidal disease
  • Anorectal fissures and fistulas
  • After proctological procedures

Why GRAMINN® suppositories?

  • Unique therapeutic option for local treatment of all forms of prostatitis
  • Strong anti-inflammatory effect enables fast relieving of symptoms
  • Creates the protective barrier which accelerates epithelialization and prevents the penetration of pathogens from the rectum
  • Prevention of swelling and fibrosis in chronic inflammation
  • Efficiently regulating the symptoms of haemorrhoidal disease, fissures and fistulas
  • Proven mechanism of action
  • Without the potential interactions and adverse effects

What do GRAMINN® suppositories contain?

Active ingredients:
GRAMINEX® NAXTM 7% (rye pollen extract)
Sodium hyaluronate
Liposoluble common mallow extract (Malva sylvestris L.)
Liposoluble marigold extract (Calendula officinalis L.)
Liposoluble aloe extract (Aloe barbadensis M.)
Clove essential oil (Eugenia caryophyllus)
Vitamin E, vitamin A

GRAMINEX® NAXTM 7% (rye pollen extract)

GRAMINEX® NAXTM 7% represents the liposoluble standardized extract from the rye pollen powder containing minimum 7% of phytosterols, fatty acid and micronutrients necessary for maintenance of health and prostate function.
GRAMINEX® NAXTM 7% inhibits the production of inflammation mediators, providing for the anti-inflammatory effect with reduction of swelling, pain, symptoms of the lower urinary tract as well as prevention of fibrosis.
Pollen powder extract has extremely high absorbency of free radicals resulting in antioxidative effect.
When applied on the mucous membrane, it builds the protective lipid barrier which maintains the required degree of hydration protects the mucous membrane from the penetration of noxa into deeper layers and accelerates the healing of erosions and fissures.

CARVACROL (Clove essential oil)

Carvacrol represents monoterpene phenol obtained from clove extract which exhibits a strong anti-inflammatory effect.
Carvacrol inhibits the activity of transcription factor NF-kB inhibiting thus the synthesis of free radicals and proinflammatory molecules.
Carvacrol accomplishes its analgesic effect through mild desensitization of TRPV receptors, reducing thus the pain as one of the most significant symptoms of acute prostatitis, painful prostate syndrome, problems with hemorrhoids, anal fissures and fistulas.

Liposoluble extracts and hyaluronic acid

Liposoluble extracts of common mallow, aloe and marigold contain slime and flavonoids in high concentration that play a role in building a protective water absorbing barrier, which is compact and elastic.
Liposoluble extracts together with hyaluronic acid have a soothing effect, provide hydration and accelerate the healing process of damaged mucosa.

Method of use

One suppository a day, best applied in the evening, before going to bed.

Length of treatment: 10 days in continuity or as advised by a doctor. Maximum length of continuous administration is 20 days.

INDICATIONS
THERAPY
Acute non-bacterial and bacterial prostatitis
GRAMINN®suppositories individually or concomitantly with antibiotics, according to the doctor’s advice
Chronic prostatitis and chronic pelvic pain syndrome
GRAMINN® suppositories , then per oral administration of GRAMINN®
Proctological diseases and after surgical treatments
GRAMINN®suppositories individually or as a part of other therapy, according to the doctor’s advice

Presentation: 10 suppositories.

Innventa pharm d.o.o.
Headquarters: No. 36/9 Šumatovačka St., 11000 Belgrade, Serbia
Representative office: No. 3 Trg pobede, 26300 Vršac, Serbia

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Prostatitis označava akutnu ili hroničnu upalu prostate. Procenjeno je da 50% svih muškaraca na svetu ima simptome upale prostate u nekom periodu svog života a prema podacima Svetske zdravstvene organizacije jedna trećina muškaraca boluje od ove bolesti. Upala prostate se najčešće se javlja kod muškaraca starosti između 20 i 40 godina, koji su i seksualno najaktivniji, kao i kod muškaraca nakon 60. godine života usled  benignog uvećanja prostate. Prostatitis negativno utiče na kvalitet života bolesnika.

Faktori rizika koji doprinose razvoju upale prostate su česte urinarne infekcije, oboljenja genitalnog sistema, instrumenatlni pregledi bešike i prostate, plasiranje katetera. Na razvoj upale prostate može da utiče i oslabljen imunitet usled bolesti ili lečenja, prisutvo bolesti drugih sistema organa, način ishrane I stil života.

U najčešće uzročnike zapaljenja prostate spadaju bakterije: Escherichia coli u 65-80% slučajeva, zatim Klebsiella, Enterobacter, Serratia, Pseudomonas  i  ređe Chlamidia, Ureaplasma i Mycoplasma. Određena medicinska stanja ili medicinski zahvati mogu da budu uzročnici nastanka upale prostate, kao što su kalkuloze genito-urinarnog trakta, suženje mokraćne cevi, benigna hiperplazija prostate, autoimune bolesti, povrede.

Vrste upale prostate: upala prostate se može javiti akutno, kada nastaje naglo, sa simptomima i znacima opšte infekcije uz pojavu smetnji u mokrenju i bolovima u predelu donjeg dela karlice ili hronična sa periodima bez simptoma između infekcija. Rutinskim mikrobiološkim metodama patogen se detektuje u samo u 5-10% slučajeva zbog čega se bolesnici tretiraju empirijski različitim medikamentima i fizikalnim postupcima.

Terapija upale prostate sprovodi se prema simtomima bolesnika, kliničnoj slici, vrsti upale i dijagnostičkim kriterijumima prema proceni lekara. Najčešće se sprovodi antibiotska terapija, terapija protiv bolova, ukoliko postoje suženja mokraćnih puteva uvode se alfa-blokatori i/ili fitoterapija.

Hemoroidna bolest, analne fisure i fistule

U najrasprostanjenije bolesti završnog dela debelog creva, rektuma i anusa, spadaju oboljenja hemoroida, analne fisure i analne fistule.

Hemoroidi predstavljaju normalne krvne sudove koji se nalaze ispod sluzokože završnog dela debelog creva, sastavljeni od arterio-venskih kanala i vezivnog tkiva, koji u fiziološkom stanju služe kao „jastučići“ koji imaju ključnu ulogu u fekalnoj kontinenciji. Usled zapaljenja i/ili oštećenja dolazi do povećanog protoka krvi i posledičnog širenja  lumena hemoroidnih krvnih sudova što izaziva simptome i znake hemoroidne bolesti.

Najčešći smiptomi oboljenja hemoroida su svrab, bol, peckanje, nelagodnost i pritisak u završnom delu debelog creva. Ponekada se javlja i krvarenje u manjem ili većem obimu u zavisnosti od lokalizacije (spoljašnje ili unutrašnje) proširenih krvnih sudova.

Faktori rizika za nastanak hemoroidne bolesti su nasleđe, ishrana, zanimanje, hronična opstipacija, trudnoća, hormonski disbalans.

Lečenje hemoroidne bolesti obuhvata promenu životnih navika, higijensko-dijetetski režim, simptomatsku terapiju i na kraju hiruško lečenje.

Analne fisure predstavljaju uzdužni rascep ili čir koji se pojavljuje u analnom kanalu, najčešće kao posledica prolaska tvrde i/ili obilne stolice. Dominatni simptom je bol dok se povremeno može javiti krvarenje. Promena životnih navika, adekvatan higijensko-dijetetski režim i simptomatska terapija su osnov tretiranja ove bolesti.

Analna  fistula je hronična povreda, u obliku tunela, koja nastaje na području analnog otvora  spontano ili nakon gnojnog procesa.  Fistule se mogu javiti kod obolelih od Kronove bolesti, zbog hroničnog zapaljenja sluzokože. Simptom koji se najčešće javlja je bol a glavna karakteristika fistule je curenje gnoja i hroničnost procesa. Lečenje može biti simptomatsko ili hiruško.

Prostatitis is an acute or chronic inflammation of the prostate. It is estimated that 50% of all men in the world have symptoms of prostate inflammation at some point in their lives, and according to the World Health Organization, one third of men suffer from this disease. Inflammation of the prostate most often occurs in men between the ages of 20 and 40, who are also the most sexually active, as well as in men after the age of 60 due to benign prostate enlargement. Prostatitis adversely affects the patient’s quality of life.

Risk factors which contribute to the development of the prostate inflammation are frequent urinary infections, genital system diseases, instrumental examinations of the bladder and prostate, catheter placement. The development of prostatitis can also be influenced by weakened immunity due to disease or treatment, the presence of diseases of other organ systems, diet and lifestyle.

The most common causes of inflammation of the prostate are bacteria: Escherichia coli in 65-80% of cases, then Klebsiella, Enterobacter, Serratia, Pseudomonas and less often Chlamydia, Ureaplasma and Mycoplasma. Certain medical conditions or medical procedures can cause inflammation of the prostate, such as calculi of the genitourinary tract, narrowing of the urethra, benign prostatic hyperplasia, autoimmune diseases, injuries.

Types of prostate inflammation: Inflammation of the prostate can be acute, when it occurs suddenly, with symptoms and signs of general infection with the appearance of urinary incontinence and pain in the lower pelvis, or chronic one with periods without symptoms between infections. Routine microbiological methods detect the pathogen in only 5-10% of cases, which is why patients are treated with empirically different medications and physical procedures.

Therapy of prostatitis is carried out according to the patient’s symptoms, clinical features, types of inflammation and diagnostic criteria according to the doctor’s assessment. Antibiotic therapy, is most often implemented, also pain therapy, and if there is narrowing of the urinary tract, alpha-blockers and / or phytotherapy are introduced.

Hemorrhoidal disease, anal fissures and fistulas

The most common diseases of the ending part of the colon, rectum and anus include haemorrhoids, anal fissures and anal fistulas.

Haemorrhoids are normal blood vessels located under the mucous membrane of the endind part of the colon, composed of arteriovenous canals and connective tissue, which in the physiological state serve as “pads” that play a key role in faecal continence. Inflammation and / or damage leads to increased blood flow and consequent dilation of the lumen of haemorrhoidal blood vessels, which causes symptoms and signs of haemorrhoidal disease.

The most common symptoms of haemorrhoids are itching, pain, tingling, discomfort and pressure in the ending part of the colon. Sometimes there is bleeding to a greater or lesser extent, depending on the location (external or internal) of dilated blood vessels.

Risk factors for the development of haemorrhoidal disease are heredity, diet, occupation, chronic constipation, pregnancy, hormonal imbalance.

Treatment of haemorrhoidal disease includes change of life habits, hygienic-dietary regime, symptomatic therapy and finally surgical treatment.

Anal fissures are a longitudinal cleft or ulcer that occurs in the anal canal, most often as a result of the passage of hard and / or copious stools. The dominant symptom is pain while bleeding may occasionally occur. Changing life habits, adequate hygienic-dietary regime and symptomatic therapy are the basis for the treatment of this disease.

Anal fistula is a chronic injury, in the form of a tunnel, which occurs in the area of the anal opening spontaneously or after a purulent process. Fistulas can occur in patients with Crohn’s disease, due to chronic inflammation of the mucous membrane. The most common symptom is pain, and the main characteristic of fistula is pus leakage and chronicity of the process. Treatment can be symptomatic or surgical.